Most recently, through her non-profit organization Social Studies 101, Weems has created, RESIST COVID/ TAKE 6!, a public art campaign in response to the disproportionate impact of COVID-19 on Black, Latino, and Indigenous communities that has been activated by museums across the nation and abroad.

Weems has participated in numerous solo and group exhibitions at major national and international museums including The Metropolitan Museum of Art, New York; The Whitney Museum of American Art, New York; Frist Center for Visual Art, Nashville; The Cleveland Museum of Art; Solomon R. Guggenheim Museum, New York; The National Gallery of Art, Washington, D.C.; The Walker Art Center, Minneapolis; and the Centro Andaluz de Arte Contemporáneo in Seville, Spain.

She is represented in public and private collections around the world including the Metropolitan Museum of Art, New York; the Museum of Fine Arts, Houston; the Museum of Modern Art,New York; Tate Modern, London; Whitney Museum of American Art, New York; National Gallery of Canada; and Museum of Contemporary Art, Los Angeles.

Ms. Weems has been represented by Galerie Barbara Thumm since 2019 and is currently Artist in Residence at the Park Avenue Armory, Syracuse University, and The Brotherhood/Sister Sol. She lives in Syracuse, New York with her husband Jeffrey Hoone who is Executive Director of Light Work.