In the 1990s, Campos-Pons explored her ancestral Yoruba and Chinese roots and the Santería tradition carried over by her Yoruba family members. Santería is a spiritual practice which was developed by African slaves in Cuba by combining influences from Yoruba and Roman Catholic religious systems. Santería is often referred to as a „woman’s religion“ as it is a religion shaped by women and practiced largely by women. The Seven Powers Come by the Sea (1992) and The Seven Powers (1994) are installations that address slavery and make mention of various Yoruba gods and goddesses. Campos-Pons’ work investigates „a felt history,“ through the intersection of „non-spoken narratives“ and „resilient culture“.

In the mid-nineties, she started using large-format photographs which were often arranged into diptychs, triptychs or other configurations. In the early 2000s, Campos-Pons returned to elements of abstraction and minimalism that were reminiscent of her early work, and admittedly influenced by her Cuban professor Antonio Vidal.

According to Campos-Pons‘ artist statement, her work „renders elements of personal history and persona” that have universal relevance. Campos-Pons says: „Of merging ideas, merging of ethnicities, merging of traditions… I am as much black, Cuban, woman, Chinese. I am this tapestry of all of that, and the responses to that could be very complicated and could include even anguish and pain.“

Her art has been shown at documenta14 in Kassel as well as in Athens, the Museum of Modern Art in New York City; the Venice Biennale; the Johannesburg Biennial; the First Liverpool Biennial; the Dakar Biennale in Senegal; and the Guangzhou Triennial in China. Campos-Pons‘ work is in the collections of the Smithsonian Institution, the Art Institute of Chicago, the National Gallery of Canada, the Victoria and Albert Museum, the Museum of Modern Art, The Museum of Fine Arts, the Miami Art Museum and the Fogg Art Museum, the Ludwig Stiftung in Aachen.

Campos-Pons currently teaches at Vanderbilt University, Nashville, Tennessee, where she is the Cornelius Vanderbilt Endowed Chair of Fine Arts. In 2020, and as a result of the nationwide social unrest, she launched “Engine for Art, Democracy and Justice“, which is defined as a Vanderbilt University „trans-institutional series of virtual conversations and artistic collaborations focused on healing at a time of significant social unrest.“